Abstract
The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome.
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MM reports grants and/or lecture honoraria from Janssen, Sanofi, Maat Pharma, JAZZ pharmaceutical, Celgene, Amgen, BMS, Takeda, Pfizer, and Roche, all outside the submitted work. FM reports lecture honoraria from Therakos/Mallinckrodt, Biocodex, Janssen, Keocyte, Sanofi, JAZZ pharmaceutical and Astellas, all outside the submitted work. AB reports honoraria from Abbvie, Novartis, Takeda, Roche, Celgene, Pfizer, Janssen and Amgen and Research support from Novartis, Takeda, Roche, Celgene and Janssen. CC reports honoraria from Kite/Gilead and Novartis. SSK is inventor on patents and royalties licensed to Novartis, Humanigen, and Mettaforge. He receives research support from Kite, Gilead, Novartis, Juno, Celgene, Humanigen, Tolero, Lentigen, Sunesis, and Morphosys. He has served on SAB for Humanigen, Kite, and Juno. M-AP reports honoraria from Abbvie, Bellicum, Bristol-Myers Squibb, Celgene, Incyte, Merck, Novartis, Nektar Therapeutics, Omeros, and Takeda. He serves on DSMBs for Servier and Medigene, and the scientific advisory boards of MolMed and NexImmune. He has received research support for clinical trials from Incyte, Kite (Gilead) and Miltenyi. IY-A reports honorarium from Gilead/Kite, Celgene, Novartis and Jansse. The other authors did not disclose any relevant conflict of interest in relation to this work
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Mohty, M., Dulery, R., Gauthier, J. et al. CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview. Bone Marrow Transplant 55, 1525–1532 (2020). https://doi.org/10.1038/s41409-020-0892-7
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DOI: https://doi.org/10.1038/s41409-020-0892-7
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