Peanut butter and jelly. Bacon and eggs. Burgers and fries. Some foods are just better together. And as it turns out, the same rule applies to vitamins and minerals, too.

That’s because many nutrients work together in synergy (which is why popping a few select supplements isn’t always the best idea). The payoff: a healthier heart.

Here are a few vitamin-and-mineral duos that can add up to big health benefits. Because in this case, the whole really is greater than the sum of its parts.

1. Pair Vitamin B6 With Magnesium to Boost Your Heart Health

The mineral magnesium, found in nuts and seeds, may help regulate your blood pressure, keep your arteries from hardening, and keep your heart rhythm regular. And it turns out that this powerful mineral has a friend: vitamin B6, which helps your body absorb magnesium.

Women ages 19 to 30 should aim for 310 milligrams (mg) a day of magnesium, while those age 31 and older should strive to get 320 mg. Men ages 19 to 30 should get 400 mg, and those age 31 and older should try for 420 mg, according to the National Institutes of Health (NIH) . Both men and women ages 19 to 50 should try to get 1.3 mg a day of vitamin B6. Men age 51 and older should get 1.7 mg, and women in the same age range should strive for 1.5 mg.

To boost your intake of magnesium, try eating foods like almonds and spinach. To get more vitamin B6, opt for raw foods that are high in the nutrient (like bananas), as opposed to cooked varieties. If you have trouble increasing your vitamin B6 intake through diet, ask your doctor whether you may benefit from a supplement.

2. A Healthy Balance of Sodium and Potassium Can Help Regulate Your Blood Pressure

These essential minerals work together like yin and yang to regulate many bodily functions, including blood pressure. Nearly half of adults in the United States have hypertension, according to the Centers for Disease Control and Prevention (CDC), and eating too much sodium and too little potassium may play a role in increasing your risk for the condition.

The American Heart Association (AHA) recommends consuming no more than 2,300 mg of sodium a day and moving toward an ideal limit of no more than 1,500 mg per day for most adults. Unfortunately, most Americans also don’t eat enough potassium, according to the U.S. Department of Agriculture (USDA) Dietary Guidelines for Americans 2020–2025. One way to strike a balance? Ditch processed foods — as 70 percent of all sodium we consume is found in packaged and restaurant foods, according to the AHA. Instead, eat lightly salted, high-potassium vegetables, like squash and spinach.

“For example, I will eat slightly undercooked organic potatoes, beans, or fish, and I salt to taste,” says James DiNicolantonio, PharmD, a cardiovascular research scientist at Saint Luke’s Mid America Heart Institute in Kansas City, Missouri. “I use salt to allow me to eat healthier high-potassium foods, which tend to be bitter without salt.” Men and women should aim to consume 3,400 and 2,600 mg of potassium, respectively. Talk to your doctor about what levels make sense for your situation.

3. Get Enough Vitamin D and Magnesium to Help Regulate Your Heart

Vitamin D can help regulate blood pressure and improve your heart health, but in order for it to work, it needs magnesium’s help. “Without magnesium, you cannot turn vitamin D into its active form, called calcitriol,” says Dr. DiNicolantonio. You don’t necessarily need to consume both nutrients in the same meal, but meeting the daily recommended intake of each is your best bet. Both men and women should aim to get 600 IU (international units) of vitamin D a day. Good sources of vitamin D include fish and milk; good sources of magnesium include almonds, spinach, and black beans.

You may have also heard of Vitamin D’s friendship with another nutrient: calcium. Together they benefit bone health. However, a review suggested that calcium supplements might be linked to a higher risk of heart trouble, so talk to your doctor before taking calcium supplements.

4. Eat Iron With Vitamin C if You Need Help Warding Off Iron-Deficiency Anemia

Iron is an essential mineral that helps your body build red blood cells. It comes in two forms: heme (found in meat and seafood) and nonheme (found in plant foods as well as meat and seafood). All adult men and women over age 51 should consume 8 mg of iron a day, while women ages 19 to 50 need 18 mg, according to the NIH.

Although iron deficiency isn’t common in the United States, says the NIH, it can occur in vegetarians because the body doesn’t absorb nonheme iron as well as it does heme iron. And untreated iron-deficiency anemia can cause your heart to work to harder, which can in turn cause irregular heartbeats or even heart failure, according to the National Heart, Lung, and Blood Institute.

If you aren’t getting enough iron, then adding vitamin C, found famously in citrus fruits (as well as berries and bell peppers, among other sources), could help because it aids iron absorption from plant foods, according to the NIH. But you can have too much of a good thing. A study found a possible link between too much iron consumption, especially from red meat, and a higher risk of atherosclerosis, a buildup of plaque inside the arteries.

That said, if you eat a lot of iron and are predisposed to storing too much iron, then getting extra vitamin C might actually be detrimental, says DiNicolantonio. Be sure to talk to your doctor about your iron and vitamin C intake.

5. Eat Vitamins B6 and B12 With Folate to Lower Your Risk of Heart Disease

These B vitamins work together to lower the levels of homocysteine, an amino acid linked to heart disease when it builds up in excess, he says. A study even suggested that higher intake of folate and vitamin B6 was associated with a lower risk of coronary heart disease in a general population.

You can find vitamin B6 in spinach; eggs, poultry, and milk contain vitamin B12. Some people might also benefit from well-formulated B-complex supplements with activated or whole-food forms of B-vitamins, says DiNicolantonio, as some individuals carry genetic MTHFR mutations that may limit their ability to process homocysteine. Just be sure to talk to your doctor before adding a supplement.

6. Pair Omega-3s With Vitamins and Minerals for a Heart-Healthy Diet

Omega-3 fatty acids are a type of polyunsaturated fat that can help keep your heart healthy, particularly if you have heart disease. There are three main types of omega-3s: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are famously found in fish, including salmon, mackerel, and albacore tuna; and alpha-linolenic acid (ALA), which is found in certain plants and plant oils, like flaxseed and canola, according to the NIH.

One of the easiest ways to increase your intake of omega-3s is by eating fish, which contain EPA and DHA — both of which are more easily absorbed by the body than ALA, says the NIH. However, according to a survey from 2022, as many as 10 percent of Americans say they are vegetarian or vegan — meaning that fish are (literally) off the table. If you don’t eat fish (for dietary, religious, or other reasons), you may want to up your intake of ALAs.

That’s because ALAs can be converted by the body into EPA and DHA — with a little help from a healthy diet, of course. Minerals like magnesium and zinc and vitamins like vitamin C and B vitamins all help to convert ALA into fatty acids like EPA and DHA, says DiNicolantonio.

Add some flaxseeds to your next salad, or sprinkle some chia seeds into your smoothie, both of which are rich in ALA.

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